Which Patients With Early HCC Should Undergo Resection?
A recent meta-analysis suggests that liver resection may be more beneficial for patients with early-stage hepatocellular carcinoma (HCC) than previously thought. Traditionally, patients with multiple liver nodules were directed towards less invasive treatments like radiofrequency ablation and transarterial chemoembolization. The study emphasizes the importance of individual patient evaluation to determine the best treatment approach.
- ▪The meta-analysis included 15 studies and 2869 patients with multinodular early-stage HCC.
- ▪Results showed that liver resection had better overall survival and disease-free survival compared to RFA and TACE.
- ▪The study highlights the need for careful patient selection, particularly for those with good hepatic reserve.
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For years, patients with early-stage hepatocellular carcinoma (HCC) who had multiple liver nodules were typically referred for less-invasive locoregional therapies such as radiofrequency ablation (RFA) and transarterial chemoembolization (TACE). The logic seemed sound: to avoid surgical trauma in people who often already have cirrhosis or limited liver function. Now, a new national multicenter meta-analysis suggests that, in carefully selected patients, this approach may need to be reconsidered.Published in the Journal of Liver Cancer, the study pooled 15 studies and 2869 patients with multinodular HCC classified as early-stage HCC — a group of individuals with multiple nodules still classified as having early-stage disease.
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Excerpt limited to ~120 words for fair-use compliance. The full article is at Medscape.
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