SIRT6 overexpression counteracts chromatin aging in the male murine liver
Research indicates that SIRT6 overexpression can counteract chromatin aging in the male murine liver. The study reveals that aging increases chromatin accessibility, leading to inflammation and metabolic decline, but SIRT6 can reverse these effects. This suggests potential therapeutic avenues for age-related chromatin changes and associated health issues.
- ▪Aging is linked to detrimental changes in chromatin structure and gene expression.
- ▪SIRT6 overexpression reverses age-related chromatin changes, reducing inflammation and enhancing metabolic function.
- ▪The study utilized a multi-omics approach, including ATAC-seq, methylome, and RNA-seq.
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Download PDF Article Open access Published: 14 May 2026 SIRT6 overexpression counteracts chromatin aging in the male murine liver Ron Nagar ORCID: orcid.org/0009-0000-2738-433X1,2 na1, Zacharia Schwartz1,2 na1, Almog Katz1,2, Noga Touitou1,2, Efrat Sharon ORCID: orcid.org/0000-0002-8430-31851, Kobi Tzdaka1, Odeya Waner1,2, Noam Shalev1,2, Rotem Clo1,2, Leah Weiss ORCID: orcid.org/0009-0006-6471-21641, Benjamin Epstein1, Michel Bernier ORCID: orcid.org/0000-0002-5948-368X3, Roni B. Shtark ORCID: orcid.org/0009-0001-4722-08234, Nirad Banskota5, Kwan-Wood G. Lam ORCID: orcid.org/0000-0003-2527-91865, Supriyo De ORCID: orcid.org/0000-0002-2075-76555, Nathan L. Price ORCID: orcid.org/0000-0002-2821-96083, Batia Lerrer1,2, Daniel Z.
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