Scientists restore memory by blocking a single Alzheimer’s protein
Researchers at Cold Spring Harbor Laboratory have found that blocking the protein PTP1B improves memory and enhances the clearance of amyloid-β plaques in mouse models of Alzheimer’s disease. The protein PTP1B interacts with SYK, which regulates microglial function, and inhibiting PTP1B appears to rejuvenate these immune cells. Given PTP1B's links to metabolic disorders like diabetes and obesity—known risk factors for Alzheimer’s—this approach may offer a multi-faceted treatment strategy.
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Science News from research organizations Scientists restore memory by blocking a single Alzheimer’s protein Date: April 30, 2026 Source: Cold Spring Harbor Laboratory Summary: Researchers have identified a new potential weapon against Alzheimer’s: blocking a protein called PTP1B. In mice, this approach boosted memory and helped brain immune cells clear harmful plaque buildup. Since PTP1B is also linked to diabetes and obesity—both risk factors for Alzheimer’s—it could offer a broader treatment strategy. Share: Facebook Twitter Pinterest LinkedIN Email FULL STORY A newly targeted protein could unlock a more powerful, multi-pronged way to slow Alzheimer’s.
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