Radiotherapy Alters Brain Vessels in Paediatric Survivors
A study found that a significant number of childhood brain cancer survivors developed cerebrovascular abnormalities 15 years after receiving radiotherapy. The most common issues identified were cavernomas and microbleeds, with quality of life remaining largely unchanged. Researchers emphasized the need for guidelines to monitor these long-term effects in survivors.
- ▪In a study of 163 survivors, 80% were diagnosed with cerebrovascular abnormalities 15 years post-radiotherapy.
- ▪Cavernomas and microbleeds were the most prevalent types of abnormalities detected.
- ▪Quality of life assessments showed minimal changes before and after MRI results were disclosed.
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TOPLINE:In a prospective study, a high proportion of survivors of childhood and adolescent brain cancer developed cerebrovascular disease 15 years post-radiotherapy, predominantly cavernomas and microbleeds, with quality of life (QOL) remaining largely unchanged after the disclosure of abnormalities.METHODOLOGY:Researchers conducted a multicentre prospective study including 163 survivors of childhood and adolescent brain tumours who received radiotherapy (median age at radiotherapy, 9.2 years) at 12 paediatric radiation oncology reference centres in France between January 1990 and December 2002.Participants underwent clinical assessment at a median interval of 15 years by a radiation oncologist or paediatric oncologist along with multimodal MRI, including angio-MRI sequences (median age…
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