Prediabetes Tied to Weight Regain After Bariatric Surgery
New research indicates that prediabetes may affect fat tissue in a way that complicates weight maintenance after bariatric surgery. Women with prediabetes showed persistent metabolic differences even after surgery, leading to greater weight regain over three years. The study suggests that targeted interventions could help improve outcomes for these patients.
- ▪Prediabetes was linked to higher glucose and insulin responses during a mixed-meal test compared to women with normal glucose tolerance.
- ▪Despite similar short-term weight loss, women with prediabetes regained significantly more weight three years post-surgery.
- ▪The study highlights the potential for targeted interventions to modify the persistent changes in fat tissue associated with prediabetes.
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TOPLINE:Prediabetes may leave a molecular “footprint” on fat tissue that makes maintaining weight loss after bariatric surgery difficult, new research showed.METHODOLOGY:Researchers divided 78 women with severe obesity (BMI, 39-49) into two groups: normal glucose tolerance (NGT; n = 43) and prediabetes (preDM; n = 35); the NGT group had fasting glucose less than 100 mg/dL and A1c less than 5.7%, whereas the prediabetes group had fasting glucose between 100 and 125 mg/dL and/or A1c between 5.7% and 6.4%.Subcutaneous fat tissue samples were collected at the time of surgery and 1 year later, and gene expression was analyzed via microarray in a subgroup of 11 women from each group.The metabolic workup included fasting glucose, insulin response, lipid profile, DEXA body composition, and liver…
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