Pediatric Ketamine Sedation Not Tied to Serious AEs
A systematic review of 67,871 children receiving intravenous ketamine for procedural sedation found that serious adverse events were extremely rare. The study reported a sentinel event rate of 0.0087%, with no deaths or permanent neurologic deficits. These findings support the safety of ketamine use in pediatric emergency care.
- ▪The pooled frequency of sentinel events during pediatric ketamine sedation was 0.0087%.
- ▪Sentinel events were more common in children older than 10 years and those with upper respiratory infections.
- ▪The study found no deaths or permanent neurologic deficits associated with ketamine sedation.
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TOPLINE:A systematic review including 67,871 children found that serious adverse events during intravenous ketamine procedural sedation in the emergency department (ED) were extremely rare, supporting the overall safety of ketamine use in pediatric emergency care.METHODOLOGY:Researchers conducted a systematic review of 20 studies including 67,871 individuals younger than 21 years who received intravenous ketamine for procedural sedation in EDs.From each study, they determined the frequency of airway and respiratory adverse events (airway obstruction, apnea, laryngospasm, and oxygen desaturation) as well as vomiting and recovery agitation.The primary outcome was a composite of serious adverse events, including sentinel events (life-threatening events such as tracheal intubation,…
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