PD Risk Significantly Higher With Schizophrenia
Research indicates that individuals with schizophrenia face a threefold increased risk of developing Parkinson's disease. The study analyzed over 42,500 adults with schizophrenia and found that certain antipsychotic medications, particularly risperidone, were linked to a higher risk of Parkinson's disease. The findings underscore the importance of monitoring patients with schizophrenia for potential neurological complications.
- ▪Patients with schizophrenia had a significantly elevated risk for Parkinson's disease compared to matched control individuals.
- ▪The use of antipsychotic medications was significantly associated with the development of Parkinson's disease.
- ▪Risperidone was linked to an increased risk for Parkinson's disease, while quetiapine was associated with a reduced risk.
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TOPLINE:Schizophrenia was associated with a threefold increased risk for Parkinson’s disease (PD), with the risk varying by the type of antipsychotic medications used, new research showed.METHODOLOGY:Investigators conducted a retrospective cohort study using records of more than 42,500 adults with schizophrenia (mean age, 66 years; 61% female) from the National Health Insurance Service database of South Korea from 2010 to 2021.These patients were propensity score-matched (1:2) with 85,041 control individuals without schizophrenia based on the Charlson comorbidity index score, age, sex, and index year.The primary outcome was incident PD, defined as new diagnoses occurring at least 1 year after the initial diagnosis of schizophrenia, requiring at least one inpatient or two outpatient…
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