Nonpharmacologics May Reduce Anxiety, Depression in SUD
A large meta-analysis indicates that nonpharmacologic interventions can significantly improve anxiety and depression symptoms in individuals with substance use disorder (SUD). Neuromodulation and mind-body therapy (MBT) were found to be particularly effective, while improvements in quality of life were less pronounced. The study highlights the variability in effectiveness based on intervention type, duration, and country development level.
- ▪The meta-analysis included 117 randomized controlled trials with 11,177 participants from 25 countries.
- ▪Significant reductions in anxiety symptoms were observed with neuromodulation, combined intervention, MBT, relapse prevention, and acupuncture.
- ▪Neuromodulation was ranked as the most effective option for anxiety and quality of life, while MBT was most effective for depression.
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TOPLINE:Nonpharmacologic interventions — particularly neuromodulation and mind-body therapy (MBT) — are associated with significant improvements in psychiatric symptoms in people with substance use disorder (SUD), a new large meta-analysis showed. However, evidence for short-term improvement in quality of life (QOL) was low.METHODOLOGY:A systematic review and network meta-analysis of 117 randomized controlled trials including 11,177 individuals (mean age, 19-57 years) with SUDs from 25 countries was conducted to compare the relative efficacy of nonpharmacologic interventions for anxiety, depression, and QOL.Intervention durations ranged from 5 days to 12 months and 19 nonpharmacologic interventions were analyzed, including neuromodulation, MBT, conventional exercise, cognitive-behavioral…
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