Measuring Drug Hypersensitivity in Pediatric Urticaria
A study on drug hypersensitivity in children with chronic spontaneous urticaria found that only 14 out of 28 suspected cases were confirmed, indicating a prevalence of 5.6%. Beta-lactam antibiotics were the most common confirmed agents, followed by nonsteroidal anti-inflammatory drugs and paracetamol. The findings suggest that drug history should be closely examined in children with chronic spontaneous urticaria.
- ▪The study involved 250 children with chronic spontaneous urticaria from January 2018 to December 2023.
- ▪Among the 28 children suspected of drug hypersensitivity, 14 were confirmed through diagnostic evaluation.
- ▪Beta-lactam antibiotics accounted for over half of the confirmed cases of drug hypersensitivity.
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TOPLINE:Drug hypersensitivity (DHS) was suspected in 28 of 250 children with chronic spontaneous urticaria (CSU), but diagnostic testing confirmed true hypersensitivity in only 14 cases, corresponding to an overall prevalence of 5.6%. Beta-lactam antibiotics were the leading confirmed agents, accounting for more than half of the confirmed cases, followed by nonsteroidal anti-inflammatory drugs and paracetamol.METHODOLOGY:Researchers conducted a nested case-control study at a tertiary referral center in Istanbul, Turkey, involving 250 children with CSU followed between January 2018 and December 2023.A total of 28 children (11.2%; 95% CI, 7.9%-15.7%) were identified as having suspected DHS based on structured clinical assessment guided by the European Network for Drug Allergy/Global Allergy…
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