Mapping molecular markers of physical fitness

A new study reveals cellular pathways that appear to underlie some differences in physical fitness. Anne Trafton | MIT News Publication Date: April 28, 2026 Press Inquiries Press Contact: Sarah McDonnell Email: [email protected] Phone: 617-253-8923 Fax: 617-258-8762 MIT News Office Close Caption: A new study shows that patterns of molecular activity in the blood may reveal not only a person’s fitness level, but also the biological processes that drive physical performance. Credits: Credit: iStock Previous image Next image Patterns of molecular activity in the blood may hold clues not only to how fit someone is, but also to the biological processes that support physical performance. Researchers at MIT, GE HealthCare, and the U.S. Military Academy at West Point have developed a computational model that links thousands of these molecular signals to fitness levels, revealing pathways that could inform future studies to improve fitness training and speed injury or disease recovery.To develop their model, the researchers analyzed more than 50,000 biomarkers in 86 cadets at the U.S. Military Academy who were training for a military competition. Using these data, the researchers were able to identify molecular pathways that appear to contribute to higher levels of physical fitness.“We had 50,000 measurements, and we wanted to get it down to about 100 where there’s some likelihood that the markers that we’re measuring are mechanistically linked to physical fitness. So, not just a statistical correlation, of which there will be many, but markers where there’s a likelihood that there is a causal relationship,” says Ernest Fraenkel, the Grover M. Hermann Professor in Health Sciences and Technology in MIT’s Department of Biological Engineering.These biomarkers can be measured by analyzing blood samples, which could offer a simple way to provide an athlete, for example, or perhaps someone with chronic illness or a long-term injury, with additional information about potential areas to focus their efforts to reduce risk of injury, accelerate recovery, or improve their performance ceiling beyond what conventional measures show.Azar Alizadeh, a principal scientist with GE HealthCare’s Healthcare Technology and Innovation Center, is the paper’s lead author. Fraenkel and Luca Marinelli, a senior principal scientist with GE HealthCare, are the senior authors of the new study, which appears in the journal Communications Biology.Mapping fitnessTo find the genetic basis of a simple trait such as height, scientists can perform large-scale studies known as genome-wide association studies (GWAS), in which genetic markers from thousands of people can be linked with height. However, the picture becomes much more complicated for traits such as physical fitness, which is determined by the interplay of many different genetic, physiological, and environmental factors.The researchers set out to try to identify some of those factors, working with a group of 86 volunteers at the U.S. Military Academy at West Point who were training for the Sandhurst Military Skills Competition. Alizadeh led the experimental study design and execution, in collaboration with GE HealthCare, GE Research, West Point, and MIT scientists. During the three-month study period, volunteers participated in up to five sessions. At each session, blood samples were taken before and after intense exercise. The researchers also measured other traits such as lean muscle mass and VO2 max (the maximum rate of…

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