Higher Abdominal Fat Linked to Faster Biological Aging
A study has found that higher abdominal fat is linked to accelerated biological aging, which increases the risk of cardiovascular disease and mortality. Researchers analyzed data from a Chinese cohort and developed biological age clocks based on various health metrics. The findings suggest that targeting abdominal obesity may help mitigate health risks associated with aging.
- ▪Abdominal adiposity was associated with accelerated biological aging across multiple measures.
- ▪Higher waist-to-hip ratio linked to faster aging was observed in all three biological age clocks studied.
- ▪MetaboAge and KDM-BA were better predictors of all-cause mortality than chronological age.
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TOPLINE:Abdominal adiposity was associated with accelerated biological aging across measures based on metabolomics, clinical biomarkers, and DNA methylation. Accelerated biological age predicted higher risks for cardiovascular (CV) disease, death, and frailty. Metabolic aging explained many of these associations.METHODOLOGY:Researchers used data from a prospective Chinese cohort to assess whether abdominal adiposity was linked to accelerated biological aging and contributed to CV and general aging.They included adults aged 30-79 who were recruited between 2004 and 2008 and were free of CV disease at baseline.
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