Fiber-Bacteria Combo May Aid Celiac Disease Recovery
A study has found that patients with celiac disease have a reduced ability to metabolize dietary fiber due to a lack of certain gut microbes. Introducing specific microbes along with soluble fiber inulin in mouse models improved gut health and mucosal healing. The research suggests that certain fibers could serve as an adjunct therapy to the gluten-free diet for better recovery.
- ▪Patients with celiac disease showed a depletion of fiber-degrading microbes like Prevotella spp.
- ▪Supplementation with inulin during a gluten-free diet improved gut health in gluten-sensitized mice.
- ▪The study indicates that the small intestinal microbiota in celiac disease patients contains fewer fiber-degrading bacteria, regardless of diet.
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TOPLINE:Patients with celiac disease had a reduced ability to metabolize dietary fiber in the small intestine due to a depletion of fiber-degrading microbes, such as Prevotella spp., regardless of treatment with a gluten-free diet. In preclinical mouse models, introducing microbes from the Prevotellaceae family together with a diet enriched in the soluble fiber inulin increased small intestinal levels of short-chain fatty acids, metabolites that support gut health and mucosal healing.METHODOLOGY:Although a lifelong gluten‑free diet is the only treatment for celiac disease, it can cause nutrient shortfalls, such as low fiber intake; furthermore, although the duodenal microbiota is altered in patients with celiac disease, its effect on microbial fiber metabolism in the small intestine…
Excerpt limited to ~120 words for fair-use compliance. The full article is at Medscape.
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