Expanding the human proteome with microproteins and peptideins – Nature
A recent study has expanded the understanding of the human proteome by focusing on microproteins and peptideins. The research highlights the importance of non-canonical open reading frames (ncORFs) in producing small proteins that contribute to human biology. The findings were made by the TransCODE Consortium, which analyzed a large dataset of proteomics experiments.
- ▪The study reveals that approximately 25% of analyzed ncORFs produce detectable peptides.
- ▪This research is significant for advancing knowledge in biomedical science and human health.
- ▪The TransCODE Consortium developed a new annotation framework for microproteins derived from ncORFs.
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Download PDF Article Open access Published: 06 May 2026 Expanding the human proteome with microproteins and peptideins Eric W. Deutsch ORCID: orcid.org/0000-0001-8732-09281 na1, Leron W. Kok ORCID: orcid.org/0009-0008-0841-23132,3 na1, Jonathan M. Mudge ORCID: orcid.org/0000-0003-4789-74954 na1, Cristian F. Valls ORCID: orcid.org/0009-0000-0517-10695,6 na1, Irwin Jungreis ORCID: orcid.org/0000-0002-3197-53677,8 na1, Jorge Ruiz-Orera ORCID: orcid.org/0000-0002-8317-00349, Zhi Sun ORCID: orcid.org/0000-0003-3324-68511, Ulrike Kusebauch ORCID: orcid.org/0000-0001-6162-75771, Ivo Fierro-Monti ORCID: orcid.org/0000-0002-5460-21174,10, Jennifer G. Abelin ORCID: orcid.org/0000-0001-5262-72418, M. Mar Alba ORCID: orcid.org/0000-0002-7963-737511,12, Julie L.
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