Cotrimoxazole Tied to More AEs in Older Men With UTIs
A study found that older men with urinary tract infections (UTIs) using cotrimoxazole experienced nearly double the risk of adverse events compared to those using fluoroquinolones. The research highlighted a higher rate of treatment discontinuation due to adverse events in the cotrimoxazole group. The findings suggest that antibiotic selection should prioritize tolerability, especially in frail older patients.
- ▪Older adults with UTIs using cotrimoxazole faced a 2.10 adjusted odds ratio for adverse events compared to fluoroquinolone users.
- ▪The study assessed 228 patients with a median age of 85 years across eight hospitals in France from 2019 to 2023.
- ▪48.5% of patients on cotrimoxazole experienced adverse events, compared to 29.7% on fluoroquinolones.
- ▪Discontinuation of treatment due to adverse events was more common in the cotrimoxazole group at 11.3% versus 2.3% for fluoroquinolones.
- ▪Acute kidney injury and metabolic disorders were the most frequent adverse events associated with cotrimoxazole.
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TOPLINE:Older adults with urinary tract infections (UTIs) who used cotrimoxazole faced approximately double the risk of developing adverse events (AEs) compared with those who used fluoroquinolones. They also had more treatment discontinuations due to AEs.METHODOLOGY:Researchers conducted a retrospective study across eight hospitals in France to assess the rates of AEs during treatment with fluoroquinolones vs cotrimoxazole in older men with UTIs treated with these drugs between 2019 and 2023.A total of 228 patients with UTIs (median age, 85 years) who required at least 7 days of inpatient monitoring during treatment were assessed; of these patients, 131 received fluoroquinolones and 97 received cotrimoxazole.The primary outcome was the occurrence of at least one AE during treatment, and…
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