Comorbidities Linked to Greater Spinal Progression in AS
A study has found that higher comorbidity burden and specific extra-musculoskeletal manifestations are linked to increased spinal progression in ankylosing spondylitis (AS) patients. The research analyzed data from 1150 participants and revealed that those with two or more comorbidities experienced significantly greater radiographic progression. Uveitis and psoriasis were particularly associated with accelerated progression, highlighting the need for targeted interventions.
- ▪Higher comorbidity burden is associated with accelerated spinal radiographic progression in patients with ankylosing spondylitis.
- ▪Patients with two comorbidities showed a progression of 2.7 mSASSS units over 10 years, while those with three or more had 2.3 units.
- ▪Uveitis and psoriasis were linked to greater radiographic progression, with significant differences noted in female patients with psoriasis.
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TOPLINE:Higher comorbidity burden and extra-musculoskeletal manifestations, specifically uveitis and psoriasis, were independently associated with accelerated spinal radiographic progression in patients with ankylosing spondylitis (AS).METHODOLOGY:Researchers analyzed data from an international prospective study to examine the associations of comorbidity burden and extra-musculoskeletal manifestations with radiographic progression in 1150 participants (mean age, 44 years; 75% male; 84% HLA-B27 positive) who met the modified New York criteria for AS.Participants had one or more lateral cervical or lumbar radiographs scored using the modified Stoke AS Severity Score (mSASSS ), with a score of 0 for normal vertebral corners, erosion, sclerosis, or squaring; 1 for a definite syndesmophyte;…
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