Brighter MRI signals
MIT researchers have developed new MRI sensors that can detect specific molecules in the brain and body. These sensors, known as liposomal nanoparticle reporters (LisNRs), enhance MRI signals by responding to target molecules, improving sensitivity significantly. This advancement aims to enable the measurement of important neurochemicals dynamically across the brain.
- ▪The new MRI sensors can brighten or dim signals based on specific molecular targets.
- ▪These sensors improve sensitivity over previous small-molecule sensors by amplifying the effect of target molecules.
- ▪Liposomal nanoparticles are used to package MRI contrast agents, allowing for greater signal changes in response to target molecules.
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New MRI sensors developed at MIT sensitively detect target molecules in the brain and body. Jennifer Michalowski | McGovern Institute for Brain Research Publication Date: May 27, 2026 Press Inquiries Press Contact: Julie Pryor Email: [email protected] Phone: 617-715-5397 McGovern Institute for Brain Research Close Caption: Liposomal nanoparticle reporters, or LisNRs, can brighten or dim MRI signals in response to specific molecular targets. Shown here is the water channel (magenta) that allows LisNRs to sense molecular targets, in combination with a blocking protein (green) that allows the sensors to turn on and off. Credits: Image courtesy of the researchers. Previous image Next image When doctors and scientists want to see inside a body, magnetic resonance imaging (MRI) is a powerful tool.
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Excerpt limited to ~120 words for fair-use compliance. The full article is at MIT News.