Airway Thickness on qCT Signals Heart Dysfunction in COPD
A study found that increased airway wall thickness in patients with chronic obstructive pulmonary disease (COPD) is linked to heart dysfunction. Specifically, higher airway thickness correlated with lower left ventricular ejection fraction. The research suggests that integrating cardiac assessments into COPD management could improve patient care.
- ▪Increased airway wall thickness measured on quantitative CT was correlated with reduced left ventricular ejection fraction.
- ▪Moderate-to-severe left ventricular systolic dysfunction was found in 10.7% of patients, with additional heart failure diagnoses in 25%.
- ▪The study involved 56 participants and highlighted the need for further research to validate these findings in larger cohorts.
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TOPLINE:Increased airway wall thickness (Pi10) measured on quantitative CT (qCT) during hospitalised exacerbations of chronic obstructive pulmonary disease (ECOPD) was correlated with reduced left ventricular ejection fraction (LVEF). Cardiac assessment revealed "undiagnosed" moderate-to-severe left ventricular systolic dysfunction (LVSD) in 8.9% of patients, heart failure without moderate-to-severe LVSD in 23.2%, and right heart failure in 14.3%.METHODOLOGY:A total of 56 participants hospitalised with ECOPD underwent structured cardiac assessment, including transthoracic echocardiography, CT coronary artery calcium score, 24-hour three-lead ECG monitoring, and both inspiratory and expiratory chest CT imaging.Participants (mean [SD] age, 72.5 [6.5] years; 58.9% women) had findings…
Excerpt limited to ~120 words for fair-use compliance. The full article is at Medscape.
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