Acute Kidney Injury Sets Kids Up for Chronic Kidney Disease
A recent meta-analysis indicates that children who survive acute kidney injury (AKI) face increased long-term risks for chronic kidney disease (CKD) and mortality. The study analyzed data from 39 studies involving over 16,000 children, revealing significant incidences of CKD, proteinuria, hypertension, and mortality following AKI. Researchers suggest that integrating follow-up care for AKI into pediatric health management could help identify CKD earlier and improve outcomes.
- ▪The meta-analysis included 39 studies with 16,151 children and a follow-up duration of 3 months to 18 years.
- ▪Post-AKI cumulative incidences were found to be 17% for CKD, 20% for proteinuria, 16% for hypertension, and 6% for mortality.
- ▪Children with AKI had higher odds of developing CKD compared to those without AKI, particularly in stages 2-3 of AKI.
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TOPLINE:Children who survived acute kidney injury (AKI) showed increased long-term risks for chronic kidney disease (CKD) and death, according to a meta-analysis.METHODOLOGY:Researchers conducted a systematic review and meta-analysis to determine late adverse outcomes in children who survived AKI.They included studies involving children who survived AKI and had a follow-up duration of at least 3 months.Outcomes of interest were the pooled incidence and odds of CKD, mortality, hypertension, and proteinuria after AKI.Researchers evaluated the quality of studies and risk of bias using relevant tools.TAKEAWAY:The review included 39 studies with 16,151 children, and the follow-up duration ranged from 3 months to 18 years.Post-AKI pooled cumulative incidences were 17% for CKD (28 studies), 20%…
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