Accuracy of Proposed CTE Diagnostic Criteria Questioned
A recent study questions the validity of proposed clinical criteria for diagnosing chronic traumatic encephalopathy (CTE). Only 24% of individuals meeting the criteria were found to have CTE pathology at autopsy. Experts express concerns about the psychological impact of misdiagnosis on athletes.
- ▪A study found that only six out of 25 individuals meeting the criteria for traumatic encephalopathy syndrome had confirmed CTE pathology.
- ▪The overall prevalence of CTE neuropathologic change in the study population was about 1.3%.
- ▪Experts caution that the study's low prevalence of CTE may affect the positive predictive value of the criteria.
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Most people who meet the proposed clinical criteria for chronic traumatic encephalopathy (CTE) during life do not have hallmark disease pathology at autopsy.A retrospective autopsy validation study showed that of 25 individuals only six (24%) met the criteria for traumatic encephalopathy syndrome (TES) — the proposed clinical syndrome associated with CTE — had CTE neuropathology at autopsy.“It is far more likely that someone who meets the current clinical criteria does not have CTE than that they do,” lead author John D.
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